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VIrus Particle ExploreR(VIPER)db
is a repository of virus capsid structures available in
the Protein Databank (PDB) and also a
relational database for informatics in structural virology. Multiscale modeling tools have been developed to analyze
protein-protein interactions, viral surfaces, energetics, assembly pathways, capsid dynamics
and aspects of chemical biology in viruses.
The results are used to annotate results from X-ray crystallography
and molecular virology. Currently, all of the viral capsids are oriented in a single
icosahedral convention. The coordinates and the derived results are integrated into a relational database
Shown below is a gallery of the biggest virus structures available in the databse
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There are currently 81 unique entries (200 in total) from 23 different families and 35
genera in the database. Each entry is described in terms of its structure, at different
levels of organization, related information on capsid size, T number, and with links to primary
sequence data in SWISS-PROT/GENBANK databases. Additionally, each capsid is annotated through
the description of the residue pairs contacting at protein-protein interfaces, buried surface areas,
solvation energies, association energies and exposed surface residues as derived from computational
analysis.
Shown below is a ribbon diagram of the canonical beta-barrel motif seen in the majority
of viral capsids.
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A number of server-side web based tools and utilites for structural analysis, visualization
of virus structures and to query the database are avialble at the
VIPERdb site.
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